Phase Correction for Absorption Mode Two-Dimensional Mass Spectrometry

Phase Correction for Absorption Mode Two-Dimensional Mass Spectrometry

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Two-dimensional mass spectrometry (2D MS) is a tandem mass spectrometry method that relies on manipulating ion motions to correlate precursor and fragment ion signals.2D mass spectra are obtained by performing a Fourier transform in both the ww2 glider infantry uniform precursor ion mass-to-charge ratio (m/z) dimension and the fragment ion m/z dimension.The phase of the ion signals evolves linearly in the precursor m/z dimension and quadratically bang xxl switch duo in the fragment m/z dimension.This study demonstrates that phase-corrected absorption mode 2D mass spectrometry improves signal-to-noise ratios by a factor of 2 and resolving power by a factor of 2 in each dimension compared to magnitude mode.

Furthermore, phase correction leads to an easier differentiation between ion signals and artefacts, and therefore easier data interpretation.